REVIEW ARTICLE


Nutraceuticals for Promoting Longevity



Ivan Pavlović1, Soliman Khateb2, 3, Irina Milisav4, 5, Jamal Mahajna6, 7, *
1 Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, Mike Petrovica Alasa 12-14, 11351 Belgrade, Serbia;
2 Laboratory of Natural Compounds and Analytical Chemistry, Migal- Galilee Research Institute Kiryat Shmona, Kiryat Shmona, 11016, Israel;
3 Department of Biotechnology, Faculty of Sciences and Technology, Tel-Hai College, Kiryat Shmona, Israel;
4 Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Zaloska 4, SI-1000 Ljubljana, Slovenia;
5 Laboratory of Oxidative Stress Research, Faculty of Health Sciences, University of Ljubljana, Zdravstvena Pot 5, SI-1000 Ljubljana, Slovenia;
6 Department of Nutrients and Natural Products, Migal- Galilee Research Institute, Kiryat Shmona, 11016, Israel;
7 Department of Nutritional Sciences, Faculty of Sciences and Technology, Tel-Hai College, Kiryat Shmona, Israel

Article Information


Identifiers and Pagination:

Year: 2020
Volume: 1
Issue: 1
First Page: 18
Last Page: 32
Publisher ID: CNT-1-18
DOI: 10.2174/2665978601666200213121512

Article History:

Received Date: 30/10/2019
Revision Received Date: 22/01/2020
Acceptance Date: 22/01/2020
Electronic publication date: 17/03/2020

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Creative Commons License
Copyright: 2020 Jamal Mahajna

* Address correspondence to this author at the Department of Nutrients and Natural Products, Migal- Galilee Research Institute, Kiryat Shmona, 11016, Israel and Department of Nutritional Sciences, Faculty of Sciences and Technology, Tel-Hai College, Kiryat Shmona, Israel; E-mail: jamalm@migal.org.il


Abstract

Objective: To summarize the main findings on nutraceuticals that slow aging processes by delaying and even preventing the development of multiple chronic diseases and improve productivity and quality of life in the elderly.

Methods: Literature search of the relevant papers known to the authors was conducted.

Results: The most robust environmental manipulation for extending lifespan is caloric restriction without malnutrition. Some nutraceuticals can mimic caloric restriction effects. This review will focus on the nutraceuticals that impact insulin-like growth factor 1 receptor signaling and sirtuin activity in mediating longevity and healthspan.

Conclusion: Aging is considered to be synonymous with the appearance of major diseases and an overall decline in physical and mental performance. Caloric restriction is well established as a strategy to extend lifespan without malnutrition. A variety of nutraceuticals were reported to mimic the effect of caloric restriction by modulating the activity of insulin-like growth factor 1 receptor signaling and sirtuin activity and consequently promote longevity and healthspan.

Keywords: Nutraceuticals, longevity, caloric restriction, insulin-like growth factor 1 receptor (IGF1R), silent mating type information regulation 2 homology 1 (SIRT1).