REVIEW ARTICLE


Recent Reports of Plants as DNA Protection Agents



Muniba Raza1, Salma Batool1, *, Rabia Razzaq2, Laiba Asim1, Farah Deeba3, Muhammad Farhan Sohail4, 5, Muhammad Sheeraz Ahmad6, Rahman Shah Zaib Saleem7, *
1 Department of Biochemistry, Faculty of Life Sciences, University of Central Punjab, Lahore 54000, Pakistan;
2 Department of Biotechnology, Faculty of Life Sciences, University of Central Punjab, Lahore 54000, Pakistan;
3 Department of Biochemistry and Biotechnology, The Woman University, Multan 66000, Pakistan;
4 Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;
5 Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, Lahore, Pakistan;
6 National Center of Industrial Biotechnology (NCIB), PMAS-ARID Agriculture University, Rawalpindi, Pakistan;
7 Department of Chemistry and Chemical Engineering, SBA School of Science and Engineering (SBASSE), Lahore University of Management Sciences (LUMS), Lahore, 54792, Pakistan

Article Information


Identifiers and Pagination:

Year: 2021
Volume: 2
Issue: 4
First Page: 293
Last Page: 300
Publisher ID: CNT-2-293
DOI: 10.2174/2665978602666210907110945

Article History:

Received Date: 10/02/2021
Revision Received Date: 11/06/2021
Acceptance Date: 29/07/2021
Electronic publication date: 07/09/2021

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Creative Commons License
Copyright: 2021 Bentham Science Publishers

Correspondence: Address correspondence to these authors at the Department of Biochemistry, Faculty of Life Science, University of Central Punjab, Lahore 54000, Pakistan; Tel: +923435622735; E-mail: salma.batool@ucp.edu.pk; Department of Chemistry and Chemical Engineering, SBA School of Science and Engineering (SBASSE), Lahore University of Management Sciences (LUMS), Lahore, 54792, Pakistan; Tel: +924235608215; Fax: +924235725048; E-mail: rahman.saleem@lums.edu.pk


Abstract

Background: DNA damage induced by reactive oxygen species (ROS) leads to cell death, tissue damage and may contribute towards the onset of several chronic diseases.

Objective: Plants carry a cocktail of compounds like flavonoids, polyphenolics, tannins, saponins, terpenoids, and alkaloids that have shown promising pharmacological potential in treating various illnesses responsible for high mortality. Some of the plant-derived compounds carry the potential to shield the DNA from damage induced by reactive oxygen species (ROS). The objective of this article is to present recent reports of plant extracts and natural products as DNA protecting agents in one place.

Methods: This review summarizes the plant-based extracts and isolated compounds with promising DNA protection activities against ROS induced damage. The antioxidant potential of plants is assessed using various antioxidant assays like DPPH assay, FRAP assay, and H 2O 2 assay. Further, the DNA protection of the extract is validated by using a plasmid protection assay. The mechanism of protection generally involves the scavenging of ROS by the antioxidants present in plant extracts.

Results and Conclusion: This review summarizes the work done on plant-based compounds for their antioxidant and DNA protection abilities in vitro. However, in vivo evaluation of promising plants is the need of time.

Keywords: Reactive oxygen species, antioxidants, DNA protection, plant extract, natural products, DNA damage.