RESEARCH ARTICLE
Anticancer Potential of Lepidium Sativum Seeds Aqueous Extract on the Azoxymethane/ Dextran Sulfate Sodium-Induced Colon Cancer In vivo
Nahed Ahmed Hussien*, 1, 2, Ghazwaa Awad Alsulami1
Article Information
Identifiers and Pagination:
Year: 2020Volume: 2
Issue: 1
First Page: 78
Last Page: 88
Publisher ID: CNT-2-78
DOI: 10.2174/2665978601999200928212236
Article History:
Received Date: 04/06/2020Revision Received Date: 29/08/2020
Acceptance Date: 03/09/2020
Electronic publication date: 28/09/2020
Abstract
Background: Colon cancer is responsible for increasing the death rate worldwide. Commonly used anticancer drugs have various side effects and their clinical usage must be restricted due to their toxicity.
Objective: The present research aimed to evaluate the anticancer potential of Lepidium sativum L. (LS) seeds aqueous extract against azoxymethane/dextran sodium sulfate (AOM/DSS) induced-colon cancer in male albino mice.
Methods: Low (200 mg/kg) and high (400 mg/kg) doses of LS seeds extract were used to treat induced colon cancer in different stages.
Results: The present results report that LS treatment for mice with colon cancer especially in high dose, decreases colon polyps/tumor incidence and size, tissues disorder, expression of P53 and increases apoptosis in colon tissue. Moreover, LS decreases micronucleus induction in polychromatic (PCE), increases PCE/normochromatic erythrocytes ratio and decreases the percentage of sperm abnormalities.
Conclusion: The present study reports anticancer potential of LS for induced colorectal cancer mice by ameliorating the inflammatory steps of colon.
