RESEARCH ARTICLE


Anticancer Potential of Lepidium Sativum Seeds Aqueous Extract on the Azoxymethane/ Dextran Sulfate Sodium-Induced Colon Cancer In vivo



Nahed Ahmed Hussien*, 1, 2, Ghazwaa Awad Alsulami1
1 Biology Department, Faculty of Science, Taif University, Al-Hawyeia 888, Kingdom of Saudi Arabia;
2 Zoology Department, Faculty of Science, Cairo University, Giza12613, Egypt

Article Information


Identifiers and Pagination:

Year: 2020
Volume: 2
Issue: 1
First Page: 78
Last Page: 88
Publisher ID: CNT-2-78
DOI: 10.2174/2665978601999200928212236

Article History:

Received Date: 04/06/2020
Revision Received Date: 29/08/2020
Acceptance Date: 03/09/2020
Electronic publication date: 28/09/2020

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Copyright: 2021 Bentham Science Publishers

* Address correspondence to this author at the Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt; Tel.: +20 2 35676781, Fax: +20 2 35727556; Email: nahed@sci.cu.edu.eg; nahed199@gmail.com; n.nahed@tu.edu.sa


Abstract

Background: Colon cancer is responsible for increasing the death rate worldwide. Commonly used anticancer drugs have various side effects and their clinical usage must be restricted due to their toxicity.

Objective: The present research aimed to evaluate the anticancer potential of Lepidium sativum L. (LS) seeds aqueous extract against azoxymethane/dextran sodium sulfate (AOM/DSS) induced-colon cancer in male albino mice.

Methods: Low (200 mg/kg) and high (400 mg/kg) doses of LS seeds extract were used to treat induced colon cancer in different stages.

Results: The present results report that LS treatment for mice with colon cancer especially in high dose, decreases colon polyps/tumor incidence and size, tissues disorder, expression of P53 and increases apoptosis in colon tissue. Moreover, LS decreases micronucleus induction in polychromatic (PCE), increases PCE/normochromatic erythrocytes ratio and decreases the percentage of sperm abnormalities.

Conclusion: The present study reports anticancer potential of LS for induced colorectal cancer mice by ameliorating the inflammatory steps of colon.

Keywords: Lepidium sativum, colitis, colorectal cancer, azoxymethane, dextran sodium sulfate, male albino mice.