RESEARCH ARTICLE


Role of Natural Plant Products Against Hemagglutinin-esterase (HE) of Human Coronavirus



Mantasha Idrisi1, Mohd Shahid1, Falaq Naz2, Yasir Hasan Siddique2, *
1 Department of Chemistry, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India;
2 Department of Zoology, Faculty of Life Sciences, Drosophila Transgenic Laboratory, Section of Genetics, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India

Article Information


Identifiers and Pagination:

Year: 2022
Volume: 3
Issue: 2
E-location ID: e230222201366
Publisher ID: e230222201366
DOI: 10.2174/2665978603666220223093343

Article History:

Received Date: 06/07/2021
Revision Received Date: 15/11/2021
Acceptance Date: 15/12/2021
Electronic publication date: 10/05/2022

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Copyright: 2022 Bentham Science Publishers

* Address correspondence to these authors at the Department of Zoology, Faculty of Life Sciences, Drosophila Transgenic Laboratory, Section of Genetics, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India; E-mail: yasir_hasansiddique@rediffmail.com


Abstract

Background: COVID-19 has spread worldwide and become a great cause of economic and social loss. Due to the non-availability of effective medicine/drug, its control has become a difficult task.

Objective: In the present study, the effect of some selected natural plant products was studied on the Hemagglutinin-esterase of the human coronavirus by performing molecular docking.

Methods: Molecular docking study for some selected natural plant products against Hemagglutinin-Esterase (HE) of human coronavirus was performed using the HEX 8.0.0 software.

Results: The free binding energy ranged from -298.14 to -161, with that of curcumin being the highest.

Conclusions: The results suggest that the natural plant products could act as possible anti-viral agents and may be used as natural therapeutic agents.

Keywords: Coronavirus, natural plant products, molecular docking, hemagglutinin-esterase, non-covalent interactions, protein-ligand.