RESEARCH ARTICLE


An Open-label Exploratory Study Investigating BDNF Essentials® on Cognition in Healthy Adults with Self-reported Memory Complaints



Erin D. Lewis1, David C. Crowley1, Debby Hamilton2, Najla Guthrie1, Malkanthi Evans1, *
1 KGK Science Inc., London, Ontario, Canada;
2 Researched Nutritionals, LLC, Los Olivos, California, USA

Article Information


Identifiers and Pagination:

Year: 2023
Volume: 4
E-location ID: e171123223619
Publisher ID: e171123223619
DOI: 10.2174/0126659786256669230930114915

Article History:

Received Date: 27/04/2023
Revision Received Date: 22/06/2023
Acceptance Date: 07/07/2023
Electronic publication date: 17/11/2023

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Creative Commons License
Copyright: 2023 Bentham Science Publishers

* Address correspondence to this author at the KGK Science Inc., 275 Dundas Street, Tower A Suite A1605 London, ON N6B 3L1, Canada, USA; E-mail: mevans@kgkscience.com


Abstract

Background

An open-label, exploratory study has been conducted to investigate the efficacy of BDNF Essentials® for cognitive function and neurological health.

Methods

Twenty healthy adults ≥45 years of age, with a score ≥24 on the Mini-Mental State Examination (MMSE-2) and self-reported memory complaints were supplemented with BDNF Essentials® for 84 days. Computerized Mental Performance Assessment System (COMPASS) tests for memory, attention, and processing speed were conducted, and change in plasma brain-derived neurotrophic factor (BDNF), Profile of Mood States (POMS), the Healthy People Sleep Quality Index (HPSQI), perceived stress scale (PSS), and salivary cortisol, interleukin (IL)-6, and tumour necrosis factor-α (TNF-α) were assessed at baseline and days 28, 56, and 84.

Results

Supplementation with BDNF Essentials® significantly increased COMPASS tests for memory, attention, and processing speed (all p < 0.05). Salivary cortisol was found to be significantly decreased at days 56 and 84 (p < 0.05), and IL-6 decreased at day 84 (P > 0.05). A reduction in depression-dejection at day 56 and in confusion-bewilderment at day 84, and an improvement in sleep satisfaction at day 56 (all p < 0.05) were reported.

Conclusion

BDNF Essentials® improved reaction time in measures of working memory, episodic memory, and attention, reduced biomarkers of stress and inflammation, and improved mood and sleep. BDNF Essentials® has been found to be safe and well-tolerated in adults with self-reported memory complaints.

Registration Number

Registered at Clinicaltrials.gov (NCT04860778).

Keywords: Cognition, BDNF, stress, inflammation, nutraceutical, dietary supplement.